O-GlcNAcylation Determines the Solubility, Filament Organization, and Stability of Keratins 8 and 18*
نویسندگان
چکیده
منابع مشابه
formation and evolution of regional organizations: the case study of the economic cooperation organization (eco)
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15 صفحه اولFunctional Implications of O-GlcNAcylation-dependent Phosphorylation at a Proximal Site on Keratin 18.
Keratins 8/18 (K8/18) are phosphoglycoproteins and form the major intermediate filament network of simple epithelia. The three O-GlcNAcylation (Ser(29), Ser(30), and Ser(48)) and two phosphorylation (Ser(33) and Ser(52)) serine sites on K18 are well characterized. Both of these modifications have been reported to increase K18 solubility and regulate its filament organization. In this report, we...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.m109.098996